Intervention library

What helps. What might. What has not earned your attention yet.

Nara reads the difficult science, separates usefulness from novelty, and gives you the conclusion first. The full evidence is still here when you want it.

A conclusion is clearer when evidence, safety, relevance, and action stay separate.
MethodologyFive questions, never one scoreOpen the framework only when you want to see how Nara separates the evidence.
Evidence maturity
How far the research has actually progressed for a specific claim.
Evidence directness
Whether the evidence is in dogs, in another species, or mechanistic only.
Safety certainty
How well the risk profile is characterized — separately from efficacy.
Personalized relevance
Whether it applies to this dog, right now, given the profile we hold.
Actionability
Who should be making the decision, and in what setting.
Review depth
Full reviews carry claim-level evidence. Briefings give a bounded position. Watchlist entries stay deliberately light until the review is complete.

For your dog

Loading your dog’s context…

01

Foundations

The boring interventions may still matter most. These have the strongest and most direct canine support, and they are owner-directed.

Foundations

Healthy body condition

Keeping a dog lean across life is the single best-supported lever an owner directly controls.

Owner-directed foundation

Supported · Canine lifespan outcomes

Evidence assessed · 2026-08-12

Foundations

Nutrition

Diet completeness, calorie accuracy, and feeding pattern — the substrate everything else sits on.

Owner-directed foundation

Established · Canine healthspan or clinical outcomes

Evidence assessed · 2026-08-12

Foundations

Protein adequacy

Whether an ageing dog is getting enough high-quality protein to defend lean mass.

Owner-directed foundation

Supported · Canine biomarkers

Evidence assessed · 2026-08-12

Foundations

Exercise

Volume, intensity, and variety of loading across a dog's week.

Owner-directed foundation

Supported · Canine functional outcomes

Evidence assessed · 2026-08-12

Foundations

Muscle preservation

Defending lean mass through mid and late life, rather than reacting to visible loss.

Owner-directed foundation

Supported · Canine lifespan outcomes

Evidence assessed · 2026-08-12

Foundations

Dental health

Periodontal disease is the most common diagnosis in adult dogs, it is painful, and it is largely preventable at home.

Owner-directed foundation

Supported · Canine healthspan or clinical outcomes

Evidence assessed · 2026-08-12

Foundations

Preventive care

Screening cadence, early detection, and baseline diagnostics before decline is visible.

Veterinary or clinical context

Supported · Canine observational evidence

Evidence assessed · 2026-08-12

Foundations

Vaccination and parasite prevention

Risk-appropriate protection against preventable disease burden.

Veterinary or clinical context

Established · Canine healthspan or clinical outcomes

Evidence assessed · 2026-08-12

02

Optimization

Reasonable additions once the foundations are in place, usually for a defined purpose rather than for everything.

03

Emerging

Early evidence is not proof. It is not nothing, either. These are worth understanding and, in some cases, worth following closely.

04

Experimental and investigational

Scientifically serious, not ready for routine owner-directed use. Listed here so you can understand them — not because Nara recommends them.

Experimental and investigational

Senolytics

Clearing senescent cells — a strong mechanism with thin canine data.

Research watchlist

Preliminary · Canine healthspan or clinical outcomes

Evidence assessed · 2026-08-12

Experimental and investigational

Rapamycin

The most scientifically important experimental canine longevity intervention, and still a medication-level decision.

Clinical-trial context only

Insufficient or conflicting · Canine functional outcomes

Evidence assessed · 2026-08-12

Experimental and investigational

LOY-001

An investigational large-breed longevity candidate targeting IGF-1 signalling.

Clinical-trial context only

Hypothesis-generating · Canine biomarkers

Evidence assessed · 2026-08-12

Experimental and investigational

LOY-002

An investigational senior-dog longevity candidate.

Clinical-trial context only

Hypothesis-generating · Canine safety or pharmacokinetics

Evidence assessed · 2026-08-12

Experimental and investigational

BPC-157

A synthetic peptide widely promoted online with very thin canine data.

Clinical-trial context only

Preliminary · Canine safety or pharmacokinetics

Evidence assessed · 2026-08-12

Experimental and investigational

TB-500

A thymosin beta-4 fragment marketed for tissue repair.

Clinical-trial context only

Insufficient or conflicting · Non-canine preclinical evidence

Evidence assessed · 2026-08-12

Experimental and investigational

MOTS-c

A mitochondrial-derived peptide studied for metabolic signalling.

Clinical-trial context only

Preliminary · Non-canine preclinical evidence

Evidence assessed · 2026-08-12

Experimental and investigational

Thymosin alpha-1

An immunomodulatory peptide with limited canine data.

Not currently supported

Insufficient or conflicting · Human clinical outcomes

Evidence assessed · 2026-08-12

Experimental and investigational

Epitalon

A synthetic peptide promoted for telomere effects on very thin evidence.

Not currently supported

Insufficient or conflicting · Non-canine preclinical evidence

Evidence assessed · 2026-08-12

Experimental and investigational

Stem-cell therapies

Cell-based approaches, mostly studied for specific orthopaedic indications.

Veterinary or clinical context

Preliminary · Canine healthspan or clinical outcomes

Evidence assessed · 2026-08-12

Experimental and investigational

Gene therapies

Early-stage genetic approaches to age-related decline.

Clinical-trial context only

Hypothesis-generating · Canine healthspan or clinical outcomes

Evidence assessed · 2026-08-12

Priority before novelty

Interesting is not the same as important.

Nara keeps every serious intervention visible, then compares it with the higher-confidence opportunities already present in your dog’s plan.

Build my dog’s plan