What is known
Experimental canine challenge studies demonstrate strong protection from major vaccine-preventable diseases following appropriate vaccination, and current veterinary guidelines distinguish core vaccination from exposure-dependent or regional decisions. Large post-vaccination datasets document that adverse events are uncommon but real and vary with factors such as dog size and number of vaccines administered at one visit. Controlled field studies also demonstrate high efficacy of specific parasite-prevention products against defined parasites, while product performance and parasite resistance are not interchangeable across agents or locations.